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Bird Neurons Use Three Times Less Glucose Than Mammalian Neurons

Summary: Neurons in the brains of birds are more energy efficient than in mammalian brains.

Source: Cell Press

Birds have impressive cognitive abilities and show a high level of intelligence. Compared to mammals of about the same size, the brains of birds also contain many more neurons.

Now a new study reported in Current Biology on September 8 helps to explain how birds can afford to maintain more brain cells: their neurons get by on less fuel in the form of glucose.

“What surprised us the most is not, per se, that the neurons consume less glucose—this could have been expected by differences in the size of their neurons,” says Kaya von Eugen of Ruhr University Bochum, Germany.

“But the magnitude of difference is so large that the size difference cannot be the only contributing factor. This implies there must be something additionally different in the bird brain that allows them to keep the costs so low.”

A landmark study in 2016 showed that the bird brain holds many more neurons compared to a similarly sized mammalian brain, the researchers explained. Since brains generally are made up of energetically costly tissue, it raised a critical question: how are birds able to support so many neurons?

To answer this question, von Eugen and colleagues set out to determine the neuronal energy budget of birds based on studies in pigeons. They used imaging methods that allowed them to estimate glucose metabolism in the birds. They also used modelling approaches to calculate the brain’s metabolic rate and glucose consumption.

Their studies found that the pigeon brain consumes a surprisingly low amount of glucose (27.29 ± 1.57 μmol glucose per 100 g per min) when the animal is awake. That translates into a surprisingly low energy budget for the brain, especially when one compares it to mammals.

It means that neurons in the bird brain consume three times less glucose than those in the mammalian brain, on average. In other words, their neurons are, for reasons that aren’t yet clear, less costly.

Von Eugen says it’s possible the differences are related to birds’ higher body temperature or the specific layout of their brains. The bird brain is also smaller on average than the mammalian brain. But their brains retain impressive capabilities, perhaps in part due to their less costly but more numerous neurons.

Their studies found that the pigeon brain consumes a surprisingly low amount of glucose (27.29 ± 1.57 μmol glucose per 100 g per min) when the animal is awake. Image is in the public domain

“Our finding explains how birds are able to support such high numbers of neurons without compromising on processing power,” von Eugen says.

“In the long parallel evolution of birds and mammals, birds evolved smaller brains with high numbers of neurons that are capable of advanced cognitive performance.

“And it seems that the combined effect of bird-distinct elements—small neuron size, high body temperature, and bird-brain-specific layout—may have generated a possible advantage in neuronal processing of information at a higher efficiency: cheap neurons with advanced processing capacity.”

The researchers say they now want to understand more about how birds’ neurons consume less glucose. While they have ideas about how it might work, further study and testing is needed to uncover “the exact mechanistic explanation of how birds attain such a higher efficiency of neuronal processing.”

Funding: This work was supported by the Deutsche Forschungsgemeinschaft.

About this neuroscience research news

Author: Kristopher Benke
Source: Cell Press
Contact: Kristopher Benke – Cell Press
Image: The image is in the public domain

Original Research: Open access.
“Avian neurons consume three times less glucose than mammalian neurons” by Kaya von Eugen et al. Current Biology

Abstract

See also

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Avian neurons consume three times less glucose than mammalian neurons

Highlights

  • Brain tissue of awake pigeons consumes 27.29 ± 1.57 μmol glucose per 100 g per min
  • This is equal to 1.86 × 10−9 ± 0.2 × 10−9 μmol glucose per neuron per minute
  • The neuronal energy budget of pigeons is thus about 3× lower compared to mammals
  • This possibly indicates more efficient neuronal processing in the avian clade
  • Summary

    Brains are among the most energetically costly tissues in the mammalian body.

     This is predominantly caused by expensive neurons with high glucose demands.

     Across mammals, the neuronal energy budget appears to be fixed, possibly posing an evolutionary constraint on brain growth.

     Compared to similarly sized mammals, birds have higher numbers of neurons, and this advantage conceivably contributes to their cognitive prowess.

     We set out to determine the neuronal energy budget of birds to elucidate how they can metabolically support such high numbers of neurons. We estimated glucose metabolism using positron emission tomography (PET) and 2-[18F]fluoro-2-deoxyglucose ([18F]FDG) as the radiotracer in awake and anesthetized pigeons. Combined with kinetic modeling, this is the gold standard to quantify cerebral metabolic rate of glucose consumption (CMRglc).

     We found that neural tissue in the pigeon consumes 27.29 ± 1.57 μmol glucose per 100 g per min in an awake state, which translates into a surprisingly low neuronal energy budget of 1.86 × 10−9 ± 0.2 × 10−9 μmol glucose per neuron per minute. This is approximately 3 times lower than the rate in the average mammalian neuron.

     The remarkably low neuronal energy budget explains how pigeons, and possibly other avian species, can support such high numbers of neurons without associated metabolic costs or compromising neuronal signaling. The advantage in neuronal processing of information at a higher efficiency possibly emerged during the distinct evolution of the avian brain.

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